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SLC40A1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NP59 |
|---|---|
| Clone Names | 100617244 |
| Gene ID | 30061 |
|---|---|
| Other Names | Solute carrier family 40 member 1, Ferroportin-1, Iron-regulated transporter 1, SLC40A1, FPN1, IREG1, SLC11A3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC40A1 |
|---|---|
| Function | Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed:15692071, PubMed:24304836, PubMed:22178646, PubMed:29599243, PubMed:30247984, PubMed:22682227, PubMed:29237594). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Localized to the basolateral membrane of hepatocytoma WIF-B cells. |
| Tissue Location | Detected in erythrocytes (at protein level) (PubMed:23219802). Expressed in placenta, intestine, muscle and spleen (PubMed:10747949). Highly expressed in mature red blood (PubMed:29599243). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a cell membraneprotein that may be involved in iron export from duodenalepithelial cells. Defects in this gene are a cause ofhemochromatosis type 4 (HFE4).
References
Valenti, L., et al. J. Hepatol. 53(5):927-933(2010)Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Kasvosve, I., et al. Clin. Chim. Acta 411 (17-18), 1248-1252 (2010) :Saja, K., et al. Br. J. Haematol. 149(6):914-916(2010)Nunez, M.T., et al. Am. J. Physiol., Cell Physiol. 298 (3), C477-C485 (2010) :
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