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SNRNP70 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P08621 |
|---|---|
| Clone Names | 100617262 |
| Gene ID | 6625 |
|---|---|
| Other Names | U1 small nuclear ribonucleoprotein 70 kDa, U1 snRNP 70 kDa, U1-70K, snRNP70, SNRNP70, RNPU1Z, RPU1, SNRP70, U1AP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SNRNP70 |
|---|---|
| Synonyms | RNPU1Z, RPU1, SNRP70, U1AP1 |
| Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158). |
| Cellular Location | Nucleus speckle. Nucleus, nucleoplasm. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles. {ECO:0000250|UniProtKB:Q62376} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SNRNP70 mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
References
Spiluttini, B., et al. J. Cell. Sci. 123 (PT 12), 2085-2093 (2010) :Tzang, B.S., et al. J. Biomed. Sci. 17, 40 (2010) :Parente Costa, L., et al. J. Autoimmun. 33(2):121-124(2009)Hernandez, H., et al. PLoS ONE 4 (9), E7202 (2009) :Palafox Sanchez, C.A., et al. Arthritis Res. Ther. 11 (1), R27 (2009) :
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