|Other Names||U1 small nuclear ribonucleoprotein 70 kDa, U1 snRNP 70 kDa, U1-70K, snRNP70, SNRNP70, RNPU1Z, RPU1, SNRP70, U1AP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||RNPU1Z, RPU1, SNRP70, U1AP1|
|Function||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.|
|Cellular Location||Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles.|
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Provided below are standard protocols that you may find useful for product applications.
SNRNP70 mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
Spiluttini, B., et al. J. Cell. Sci. 123 (PT 12), 2085-2093 (2010) :Tzang, B.S., et al. J. Biomed. Sci. 17, 40 (2010) :Parente Costa, L., et al. J. Autoimmun. 33(2):121-124(2009)Hernandez, H., et al. PLoS ONE 4 (9), E7202 (2009) :Palafox Sanchez, C.A., et al. Arthritis Res. Ther. 11 (1), R27 (2009) :
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