|Other Names||Tight junction protein ZO-2, Tight junction protein 2, Zona occludens protein 2, Zonula occludens protein 2, TJP2, X104, ZO2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in tight junctions and adherens junctions.|
|Cellular Location||Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Nucleus. Note=Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures.|
|Tissue Location||This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues.|
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This gene encodes a zonula occluden that is a member ofthe membrane-associated guanylate kinase homolog family. Theencoded protein functions as a component of the tight junctionbarrier in epithelial and endothelial cells and is necessary forproper assembly of tight junctions. Mutation in this gene have beenidentified in patients with hypercholanemia. Alternate splicingresults in multiple transcript variants.
Lechuga, S., et al. Exp. Cell Res. 316(19):3124-3139(2010)Remue, E., et al. FEBS Lett. 584(19):4175-4180(2010)Walsh, T., et al. Am. J. Hum. Genet. 87(1):101-109(2010)Meerschaert, K., et al. Cell. Mol. Life Sci. 66(24):3951-3966(2009)Fanning, A.S., et al. Ann. N. Y. Acad. Sci. 1165, 113-120 (2009) :
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