|Other Names||Histone deacetylase complex subunit SAP30, 30 kDa Sin3-associated polypeptide, Sin3 corepressor complex subunit SAP30, Sin3-associated polypeptide p30, SAP30 (HGNC:10532)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the functional recruitment of the Sin3- histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N- CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.|
|Tissue Location||Expressed in all tissues tested with highest levels in pancreas, ovary, PBL, spleen and thymus; lowest levels in brain, placenta, lung and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
Histone acetylation plays a key role in the regulation ofeukaryotic gene expression. Histone acetylation and deacetylationare catalyzed by multisubunit complexes. The protein encoded bythis gene is a component of the histone deacetylase complex, whichincludes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and otherpolypeptides. This complex is active in deacetylating core histoneoctamers, but inactive in deacetylating nucleosomal histones. Apseudogene of this gene is located on chromosome 3. [provided byRefSeq].
Brandt, S., et al. Int. J. Biochem. Cell Biol. 42(9):1472-1481(2010)Viiri, K.M., et al. Mol. Cell. Biol. 29(2):342-356(2009)Sichtig, N., et al. Arch. Biochem. Biophys. 467(1):67-75(2007)Szafranski, K., et al. Genome Biol. 8 (8), R154 (2007) :Olsen, J.V., et al. Cell 127(3):635-648(2006)
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