|Other Names||Sulfite oxidase, mitochondrial, SUOX|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion intermembrane space.|
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Provided below are standard protocols that you may find useful for product applications.
Sulfite oxidase is a homodimeric protein localized to theintermembrane space of mitochondria. Each subunit contains a hemedomain and a molybdopterin-binding domain. The enzyme catalyzes theoxidation of sulfite to sulfate, the final reaction in theoxidative degradation of the sulfur amino acids cysteine andmethionine. Sulfite oxidase deficiency results in neurologicalabnormalities which are often fatal at an early age. Alternativesplicing results in multiple transcript variants encoding identicalproteins.
Rajapakshe, A., et al. Biochemistry 49(25):5154-5159(2010)Johnson-Winters, K., et al. Biochemistry 49(6):1290-1296(2010)Neumann, M., et al. FEBS J. 275(22):5678-5689(2008)Astashkin, A.V., et al. J. Am. Chem. Soc. 130(26):8471-8480(2008)Hakonarson, H., et al. Diabetes 57(4):1143-1146(2008)
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