|Other Names||Beta-catenin-like protein 1, Nuclear-associated protein, NAP, Testis development protein NYD-SP19, CTNNBL1, C20orf33|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.|
|Cellular Location||Isoform 1: Nucleus.|
|Tissue Location||Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid|
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The protein encoded by this gene contains an acidicdomain, a putative bipartite nuclear localization signal, a nuclearexport signal, a leucine-isoleucine zipper, and phosphorylationmotifs. In addition, the encoded protein containsArmadillo/beta-catenin-like repeats, which have been implicated inprotein-protein interactions. Although the function of this proteinhas not been determined, the C-terminal portion of the protein hasbeen shown to possess apoptosis-inducing activity. [provided byRefSeq].
Ichikawa, S., et al. J. Bone Miner. Res. 25(8):1821-1829(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Badiglian Filho, L., et al. Oncol. Rep. 21(2):313-320(2009)Andreasen, C.H., et al. BMC Med. Genet. 10, 17 (2009) :Vogel, C.I., et al. BMC Med. Genet. 10, 14 (2009) :
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