|Other Names||Deoxyhypusine synthase, DHS, DHPS, DS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post- translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF- 5A factor and is essential for its function.|
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Provided below are standard protocols that you may find useful for product applications.
The unusual amino acid hypusine is formedposttranslationally and is only found in a single cellular protein,eukaryotic translation initiation factor 5A. In the first step ofhypusine biosynthesis, deoxyhypusine synthase catalyzes theNAD-dependent transfer of the butylamine moiety of spermidine tothe epsilon-amino group of a specific lysine residue of the EIF5Aprecursor protein to form the intermediate deoxyhypusine residue.This gene consists of nine exons spanning 6.6 kb. Three transcriptvariants have been isolated. However, only transcript variant 1encodes an active protein. The shorter variants may act asmodulating factors of DHPS activity.
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Alker, A.P., et al. Trop. Med. Int. Health 13(11):1384-1391(2008)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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