|Other Names||Cartilage-associated protein, CRTAP, CASP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Found in articular chondrocytes. Expressed in a variety of tissues|
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The protein encoded by this gene is similar to the chickenand mouse CRTAP genes. The encoded protein is a scaffolding proteinthat may influence the activity of at least one member of thecytohesin/ARNO family in response to specific cellular stimuli.Defects in this gene are associated with osteogenesis imperfecta, aconnective tissue disorder characterized by bone fragility and lowbone mass.
Morello, R., et al. Curr Osteoporos Rep 8(2):77-83(2010)Li, G.H., et al. Osteoporos Int 21(6):1009-1020(2010)Fratzl-Zelman, N., et al. Bone 46(3):820-826(2010)Chang, W., et al. Hum. Mol. Genet. 19(2):223-234(2010)Marini, J.C., et al. Cell Tissue Res. 339(1):59-70(2010)
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