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CCNK Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O75909
Clone Names 110617025
Peptide ID 110617025
Additional Information
Gene ID 8812
Other Names Cyclin-K, CCNK, CPR4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCNK
Synonyms CPR4
Function Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).
Cellular Location Nucleus.
Tissue Location Ubiquitously expressed. Highest levels in testis.
Research Areas
Citations (0)

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Background

The protein encoded by this gene is a member of thetranscription cyclin family. These cyclins may regulatetranscription through their association with and activation ofcyclin-dependent kinases (CDK) that phosphorylate the C-terminaldomain (CTD) of the large subunit of RNA polymerase II. This geneproduct may play a dual role in regulating CDK and RNA polymeraseII activities.

References

Marsaud, V., et al. Mol. Cancer 9, 103 (2010) :Baek, K., et al. J. Mol. Biol. 366(2):563-573(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Lim, J., et al. Cell 125(4):801-814(2006)

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$ 80.00
Cat# BP17061a
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