|Other Names||Annexin A9, Annexin XXXI, Annexin-31, Annexin-9, Pemphaxin, ANXA9, ANX31|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes.|
|Tissue Location||Expressed in the stratified squamous skin epithelium, but not in epithelia of other types (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
The annexins are a family of calcium-dependentphospholipid-binding proteins. Members of the annexin familycontain 4 internal repeat domains, each of which includes a type IIcalcium-binding site. The calcium-binding sites are required forannexins to aggregate and cooperatively bind anionic phospholipidsand extracellular matrix proteins. This gene encodes a divergentmember of the annexin protein family in which all four homologoustype II calcium-binding sites in the conserved tetrad core containamino acid substitutions that ablate their function. However,structural analysis suggests that the conserved putative ionchannel formed by the tetrad core is intact.
Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Goebeler, V., et al. FEBS Lett. 546 (2-3), 359-364 (2003) :Nguyen, V.T., et al. J. Biol. Chem. 275(38):29466-29476(2000)Morgan, R.O., et al. Gene 227(1):33-38(1999)
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