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IQCB1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q15051
Clone Names 110617089
Peptide ID 110617089
Additional Information
Gene ID 9657
Other Names IQ calmodulin-binding motif-containing protein 1, Nephrocystin-5, p53 and DNA damage-regulated IQ motif protein, PIQ, IQCB1, KIAA0036, NPHP5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IQCB1
Synonyms KIAA0036, NPHP5
Function Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (PubMed:21565611, PubMed:23446637). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (PubMed:25552655).
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localization to the centrosome depends on the interaction with CEP290/NPHP6
Tissue Location Ubiquitously expressed in fetal and adult tissues. Localized to the outer segments and connecting cilia of photoreceptor cells. Up-regulated in a number of primary colorectal and gastric tumors.
Research Areas
Citations (0)

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This gene encodes a nephrocystin protein that interactswith calmodulin and the retinitis pigmentosa GTPase regulatorprotein. The encoded protein has a central coiled-coil region andtwo calmodulin-binding IQ domains. It is localized to the primarycilia of renal epithelial cells and connecting cilia ofphotoreceptor cells. The protein is thought to play a role inciliary function. Defects in this gene result in Senior-Lokensyndrome type 5. Alternative splicing results in multipletranscript variants.


Hildebrandt, F., et al. J. Am. Soc. Nephrol. 20(1):23-35(2009)Schafer, T., et al. Hum. Mol. Genet. 17(23):3655-3662(2008)Luo, X., et al. Cancer Res. 65(23):10725-10733(2005)le Maire, A., et al. Proteins 59(2):347-355(2005)Mollet, G., et al. Hum. Mol. Genet. 14(5):645-656(2005)

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$ 80.00
Cat# BP17066c
Availability: In Stock
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