|Other Names||Rap guanine nucleotide exchange factor 5, Guanine nucleotide exchange factor for Rap1, M-Ras-regulated Rap GEF, MR-GEF, Related to Epac, Repac, RAPGEF5, GFR, KIAA0277, MRGEF|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GFR, KIAA0277, MRGEF|
|Function||Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.|
|Tissue Location||Widely expressed with highest levels in brain.|
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Provided below are standard protocols that you may find useful for product applications.
Members of the RAS (see HRAS; MIM 190020) subfamily ofGTPases function in signal transduction as GTP/GDP-regulatedswitches that cycle between inactive GDP- and active GTP-boundstates. Guanine nucleotide exchange factors (GEFs), such asRAPGEF5, serve as RAS activators by promoting acquisition of GTP tomaintain the active GTP-bound state and are the key link betweencell surface receptors and RAS activation (Rebhun et al., 2000[PubMed 10934204]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)Hwang, S.J., et al. BMC Med. Genet. 8 SUPPL 1, S10 (2007) :Rebhun, J.F., et al. J. Biol. Chem. 275(45):34901-34908(2000)de Rooij, J., et al. J. Biol. Chem. 275(27):20829-20836(2000)
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