|Other Names||Sodium-coupled neutral amino acid transporter 4, Amino acid transporter A3, Na(+)-coupled neutral amino acid transporter 4, Solute carrier family 38 member 4, System A amino acid transporter 3, System N amino acid transporter 3, SLC38A4, ATA3, NAT3, SNAT4|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ATA3, NAT3, SNAT4|
|Function||Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels.|
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Provided below are standard protocols that you may find useful for product applications.
SLC38A4 is found predominantly in liver and transportsboth cationic and neutral amino acids. The transport of cationicamino acids by SLC38A4 is Na(+) and pH independent, while thetransport of neutral amino acids is Na(+) and pH dependent(Hatanaka et al., 2001 [PubMed 11342143]).
Desforges, M., et al. J. Physiol. (Lond.) 587 (PT 1), 61-72 (2009) :Iruloh, C.G., et al. Pediatr. Res. 65(1):51-56(2009)Broer, S. Physiol. Rev. 88(1):249-286(2008)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Desforges, M., et al. Am. J. Physiol., Cell Physiol. 290 (1), C305-C312 (2006) :
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