SLC38A4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q969I6 |
---|---|
Clone Names | 110617170 |
Gene ID | 55089 |
---|---|
Other Names | Sodium-coupled neutral amino acid transporter 4, Amino acid transporter A3, Na(+)-coupled neutral amino acid transporter 4, Solute carrier family 38 member 4, System A amino acid transporter 3, System N amino acid transporter 3, SLC38A4, ATA3, NAT3, SNAT4 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SLC38A4 (HGNC:14679) |
---|---|
Function | Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:11342143, PubMed:19015196, PubMed:33928121). The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+) (PubMed:11414754). Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L- proline and L-glutamine and L-methionine (PubMed:11414754, PubMed:33928121). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, microvillus membrane; Multi-pass membrane protein Note=Microvillus membrane localization in placenta |
Tissue Location | Expressed almost exclusively in embryonic and adult liver, and at lower levels in the kidney (PubMed:11342143, PubMed:11414754). Expressed at lower levels in adult muscle and pancreas (PubMed:11414754). Detected in fetal blood vessels (PubMed:16148032). Expressed in syncytiotrophoblas of placenta during first trimester and at term (PubMed:19015196, PubMed:16148032). Highly expressed in first trimester placenta compared to term placenta (PubMed:19015196). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
SLC38A4 is found predominantly in liver and transportsboth cationic and neutral amino acids. The transport of cationicamino acids by SLC38A4 is Na(+) and pH independent, while thetransport of neutral amino acids is Na(+) and pH dependent(Hatanaka et al., 2001 [PubMed 11342143]).
References
Desforges, M., et al. J. Physiol. (Lond.) 587 (PT 1), 61-72 (2009) :Iruloh, C.G., et al. Pediatr. Res. 65(1):51-56(2009)Broer, S. Physiol. Rev. 88(1):249-286(2008)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Desforges, M., et al. Am. J. Physiol., Cell Physiol. 290 (1), C305-C312 (2006) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.