|Other Names||Regulator of microtubule dynamics protein 3, RMD-3, hRMD-3, Cerebral protein 10, Protein FAM82A2, Protein FAM82C, Protein tyrosine phosphatase-interacting protein 51, TCPTP-interacting protein 51, RMDN3, FAM82A2, FAM82C, PTPIP51|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||FAM82A2, FAM82C, PTPIP51|
|Function||Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.|
|Cellular Location||Mitochondrion membrane; Single-pass membrane protein. Mitochondrion outer membrane. Cytoplasm. Nucleus Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles|
|Tissue Location||Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed|
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Provided below are standard protocols that you may find useful for product applications.
FAM82A2 may participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.
Koch, P., et al. Prostate 69(16):1751-1762(2009)Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Barop, J., et al. J. Histochem. Cytochem. 57(5):425-435(2009)Stenzinger, A., et al. J. Histochem. Cytochem. 57(2):143-153(2009)Koch, P., et al. J. Cell. Mol. Med. 12 (5B), 2083-2095 (2008) :
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