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WHSC1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O96028
Clone Names 100623080
Peptide ID 100623080
Additional Information
Gene ID 7468
Other Names Histone-lysine N-methyltransferase NSD2, Multiple myeloma SET domain-containing protein, MMSET, Nuclear SET domain-containing protein 2, NSD2, Protein trithorax-5, Wolf-Hirschhorn syndrome candidate 1 protein, WHSC1, WHSC1, KIAA1090, MMSET, NSD2, TRX5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name WHSC1
Synonyms KIAA1090, MMSET, NSD2, TRX5
Function Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform RE-IIBP may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267, ECO:0000269|PubMed:15677557, ECO:0000269|PubMed:16197452}. Chromosome
Tissue Location Widely expressed.
Research Areas
Citations (0)

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This gene encodes a protein that contains four domainspresent in other developmental proteins: a PWWP domain, an HMG box,a SET domain, and a PHD-type zinc finger. It is expressedubiquitously in early development. Wolf-Hirschhorn syndrome (WHS)is a malformation syndrome associated with a hemizygous deletion ofthe distal short arm of chromosome 4. This gene maps to the 165 kbWHS critical region and has also been involved in the chromosomaltranslocation t(4;14)(p16.3;q32.3) in multiple myelomas.Alternative splicing of this gene results in multiple transcriptvariants encoding different isoforms. Some transcript variants arenonsense-mediated mRNA (NMD) decay candidates, hence notrepresented as reference sequences.


Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Kang, H.B., et al. FEBS Lett. 583(12):1880-1886(2009)Kassambara, A., et al. Biochem. Biophys. Res. Commun. 379(4):840-845(2009)Brito, J.L., et al. Haematologica 94(1):78-86(2009)Li, J., et al. Neuro-oncology 10(1):45-51(2008)

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$ 80.00
Cat# BP17079b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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