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WHSC1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O96028
Clone Names 100623080
Peptide ID 100623080
Additional Information
Gene ID 7468
Other Names Histone-lysine N-methyltransferase NSD2, Multiple myeloma SET domain-containing protein, MMSET, Nuclear SET domain-containing protein 2, NSD2, Protein trithorax-5, Wolf-Hirschhorn syndrome candidate 1 protein, WHSC1, WHSC1, KIAA1090, MMSET, NSD2, TRX5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NSD2 (HGNC:12766)
Function Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267, ECO:0000269|PubMed:15677557, ECO:0000269|PubMed:16197452}. Chromosome
Tissue Location Widely expressed.
Research Areas
Citations (0)

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This gene encodes a protein that contains four domainspresent in other developmental proteins: a PWWP domain, an HMG box,a SET domain, and a PHD-type zinc finger. It is expressedubiquitously in early development. Wolf-Hirschhorn syndrome (WHS)is a malformation syndrome associated with a hemizygous deletion ofthe distal short arm of chromosome 4. This gene maps to the 165 kbWHS critical region and has also been involved in the chromosomaltranslocation t(4;14)(p16.3;q32.3) in multiple myelomas.Alternative splicing of this gene results in multiple transcriptvariants encoding different isoforms. Some transcript variants arenonsense-mediated mRNA (NMD) decay candidates, hence notrepresented as reference sequences.


Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Kang, H.B., et al. FEBS Lett. 583(12):1880-1886(2009)Kassambara, A., et al. Biochem. Biophys. Res. Commun. 379(4):840-845(2009)Brito, J.L., et al. Haematologica 94(1):78-86(2009)Li, J., et al. Neuro-oncology 10(1):45-51(2008)

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$ 80.00
Cat# BP17079b
Availability: In Stock
Bulk Size
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