|Other Names||Tubulin polymerization-promoting protein, TPPP, 25 kDa brain-specific protein, TPPP/p25, p24, p25-alpha, TPPP, TPPP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies|
|Tissue Location||Widely expressed.|
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TPPP may play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.
Tokesi, N., et al. J. Biol. Chem. 285(23):17896-17906(2010)McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)Sun, M., et al. Cell. Signal. 21(12):1857-1865(2009)Ovadi, J., et al. Bioessays 31(6):676-686(2009)Zhou, Y., et al. Leuk. Lymphoma 49(10):1945-1953(2008)
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