|Other Names||Protein NDRG4, Brain development-related molecule 1, N-myc downstream-regulated gene 4 protein, Vascular smooth muscle cell-associated protein 8, SMAP-8, NDRG4, BDM1, KIAA1180|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.|
|Cellular Location||Cytoplasm, cytosol|
|Tissue Location||Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells.|
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This gene is a member of the N-myc downregulated genefamily which belongs to the alpha/beta hydrolase superfamily. Theprotein encoded by this gene is a cytoplasmic protein that may beinvolved in the regulation of mitogenic signalling in vascularsmooth muscles cells. Several alternatively spliced transcriptvariants of this gene have been described, but the full-lengthnature of some of these variants has not been determined. [providedby RefSeq].
Rose, J. Phd, et al. Mol. Med. (2010) In press :Holm, H., et al. Nat. Genet. 42(2):117-122(2010)Schilling, S.H., et al. J. Biol. Chem. 284(37):25160-25169(2009)Melotte, V., et al. J. Natl. Cancer Inst. 101(13):916-927(2009)Pfeufer, A., et al. Nat. Genet. 41(4):407-414(2009)
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