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MPI Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P34949 |
|---|---|
| Clone Names | 100712083 |
| Gene ID | 4351 |
|---|---|
| Other Names | Mannose-6-phosphate isomerase, Phosphohexomutase, Phosphomannose isomerase, PMI, MPI, PMI1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MPI (HGNC:7216) |
|---|---|
| Synonyms | PMI1 |
| Function | Isomerase that catalyzes the interconversion of fructose-6-P and mannose-6-P and has a critical role in the supply of D-mannose derivatives required for many eukaryotic glycosylation reactions. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q924M7}. |
| Tissue Location | Expressed in all tissues, but more abundant in heart, brain and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphomannose isomerase catalyzes the interconversion offructose-6-phosphate and mannose-6-phosphate and plays a criticalrole in maintaining the supply of D-mannose derivatives, which arerequired for most glycosylation reactions. Mutations in the MPIgene were found in patients with carbohydrate-deficientglycoprotein syndrome, type Ib.
References
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :Lamesch, P., et al. Genomics 89(3):307-315(2007)Xiao, J., et al. J. Mol. Graph. Model. 25(3):289-295(2006)Vuillaumier-Barrot, S., et al. J. Med. Genet. 39(11):849-851(2002)Schollen, E., et al. Eur. J. Hum. Genet. 10(10):643-648(2002)
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