|Other Names||Mannose-6-phosphate isomerase, Phosphohexomutase, Phosphomannose isomerase, PMI, MPI, PMI1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.|
|Tissue Location||Expressed in all tissues, but more abundant in heart, brain and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
Phosphomannose isomerase catalyzes the interconversion offructose-6-phosphate and mannose-6-phosphate and plays a criticalrole in maintaining the supply of D-mannose derivatives, which arerequired for most glycosylation reactions. Mutations in the MPIgene were found in patients with carbohydrate-deficientglycoprotein syndrome, type Ib.
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :Lamesch, P., et al. Genomics 89(3):307-315(2007)Xiao, J., et al. J. Mol. Graph. Model. 25(3):289-295(2006)Vuillaumier-Barrot, S., et al. J. Med. Genet. 39(11):849-851(2002)Schollen, E., et al. Eur. J. Hum. Genet. 10(10):643-648(2002)
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