|Other Names||Eyes absent homolog 2, EYA2, EAB1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.|
|Cellular Location||Cytoplasm. Nucleus. Note=Retained in the cytoplasm via interaction with GNAZ and GNAI2. Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus|
|Tissue Location||Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the eyes absent (EYA) familyof proteins. The encoded protein may be post-translationallymodified and may play a role in eye development. A similar proteinin mice can act as a transcriptional activator. Alternativesplicing results in multiple transcript variants, but thefull-length natures of all of these variants have not yet beendetermined.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Guo, J.T., et al. Zhonghua Zhong Liu Za Zhi 31(7):528-531(2009)
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