RIC8A Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NPQ8 |
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Clone Names | 100712177 |
Gene ID | 60626 |
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Other Names | Synembryn-A, Protein Ric-8A, RIC8A |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RIC8A |
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Function | Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)- alpha-GDP complex (By similarity). Also acts as an activator for G(q)- alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q80ZG1}. Cell membrane {ECO:0000250|UniProtKB:Q80ZG1}. Note=Colocalizes with RGS14 in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). |
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Background
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
References
Woodard, G.E., et al. Mol. Cell. Biol. 30(14):3519-3530(2010)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Lim, J., et al. Cell 125(4):801-814(2006)Nishimura, A., et al. Genes Cells 11(5):487-498(2006)Tall, G.G., et al. J. Biol. Chem. 278(10):8356-8362(2003)
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