|Other Names||P2X purinoceptor 6, P2X6, ATP receptor, P2XM, Purinergic receptor, Purinergic receptor P2X-like 1, P2RX6, P2RXL1, P2X6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for ATP that acts as a ligand-gated ion channel.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed predominantly in skeletal muscle.|
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The protein encoded by this gene belongs to the family ofP2X receptors, which are ATP-gated ion channels and mediate rapidand selective permeability to cations. This gene is predominantlyexpressed in skeletal muscle, and regulated by p53. The encodedprotein is associated with VE-cadherin at the adherens junctions ofhuman umbilical vein endothelial cells. Alternative splicingresults in multiple transcript variants. A related pseudogene,which is also located on chromosome 22, has been identified.
Trynka, G., et al. Gut 58(8):1078-1083(2009)Luke, M.M., et al. Stroke 40(2):363-368(2009)Palomino-Doza, J., et al. Hypertension 52(5):980-985(2008)Shiffman, D., et al. Arterioscler. Thromb. Vasc. Biol. 28(1):173-179(2008)Dubyak, G.R. Mol. Pharmacol. 72(6):1402-1405(2007)
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