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P2RX6 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O15547 |
|---|---|
| Clone Names | 100712237 |
| Gene ID | 9127 |
|---|---|
| Other Names | P2X purinoceptor 6, P2X6, ATP receptor, P2XM, Purinergic receptor, Purinergic receptor P2X-like 1, P2RX6, P2RXL1, P2X6 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | P2RX6 |
|---|---|
| Synonyms | P2RXL1, P2X6 |
| Function | Receptor for ATP that acts as a ligand-gated ion channel. |
| Cellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed predominantly in skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the family ofP2X receptors, which are ATP-gated ion channels and mediate rapidand selective permeability to cations. This gene is predominantlyexpressed in skeletal muscle, and regulated by p53. The encodedprotein is associated with VE-cadherin at the adherens junctions ofhuman umbilical vein endothelial cells. Alternative splicingresults in multiple transcript variants. A related pseudogene,which is also located on chromosome 22, has been identified.
References
Trynka, G., et al. Gut 58(8):1078-1083(2009)Luke, M.M., et al. Stroke 40(2):363-368(2009)Palomino-Doza, J., et al. Hypertension 52(5):980-985(2008)Shiffman, D., et al. Arterioscler. Thromb. Vasc. Biol. 28(1):173-179(2008)Dubyak, G.R. Mol. Pharmacol. 72(6):1402-1405(2007)
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