|Other Names||Putative ATP-dependent RNA helicase DHX30, DEAH box protein 30, DHX30, DDX30, KIAA0890|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the assembly of the mitochondrial large ribosomal subunit (PubMed:25683715). Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA (PubMed:18063578).|
|Cellular Location||Isoform 2: Cytoplasm. Mitochondrion. Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids|
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DEAD box proteins, characterized by the conserved motifAsp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They areimplicated in a number of cellular processes involving alterationof RNA secondary structure such as translation initiation, nuclearand mitochondrial splicing, and ribosome and spliceosome assembly.Based on their distribution patterns, some members of this DEAD boxprotein family are believed to be involved in embryogenesis,spermatogenesis, and cellular growth and division. This geneencodes a member of this family. The encoded protein has 97%sequence identity with the mouse HELG protein. Alternativelyspliced transcript variants encoding distinct isoforms have beenfound for this gene.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Zhou, Y., et al. Virology 372(1):97-106(2008)Bogenhagen, D.F., et al. J. Biol. Chem. 283(6):3665-3675(2008)Takezawa, S., et al. EMBO J. 26(3):764-774(2007)
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