|Other Names||Dermokine, Epidermis-specific secreted protein SK30/SK89, DMKN|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May act as a soluble regulator of keratinocyte differentiation.|
|Tissue Location||Expressed in epidermis; in the spinous and granular layers and in placenta. Also found in the epithelia of the small intestine, macrophages of the lung and endothelial cells of the lung. Isoform 15 is expressed in epidermis and placenta Isoform 1 is expressed in epidermis.|
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This gene is upregulated in inflammatory diseases, and itwas first observed as expressed in the differentiated layers ofskin. The most interesting aspect of this gene is the differentialuse of promoters and terminators to generate isoforms with uniquecellular distributions and domain components. Alternatively splicedtranscript variants encoding different isoforms have beenidentified for this gene.
Naso, M.F., et al. J. Invest. Dermatol. 127(7):1622-1631(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Toulza, E., et al. J. Invest. Dermatol. 126(2):503-506(2006)Matsui, T., et al. Genomics 84(2):384-397(2004)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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