|Other Names||Kelch-like protein 3, KLHL3, KIAA1129|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation.|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, cytosol|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Schmutz, J., et al. Nature 431(7006):268-274(2004)Yeo, A., et al. J. Neurochem. 76(6):1688-1700(2001)Lai, F., et al. Genomics 66(1):65-75(2000)Mizutani, A., et al. J. Biol. Chem. 275(13):9823-9831(2000)
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