|Other Names||Phosphatidylserine synthase 1, PSS-1, PtdSer synthase 1, Serine-exchange enzyme I, PTDSS1, KIAA0024, PSSA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein Note=Highly enriched in the mitochondria-associated membrane (MAM).|
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Provided below are standard protocols that you may find useful for product applications.
Phosphatidylserine (PS) accounts for 5 to 10% of cellmembrane phospholipids. In addition to its role as a structuralcomponent, PS is involved in cell signaling, blood coagulation, andapoptosis. PS is synthesized by a calcium-dependent base-exchangereaction catalyzed by PS synthases (EC 188.8.131.52), like PTDSS1, thatexchange L-serine for the polar head group of phosphatidylcholine(PC) or phosphatidylethanolamine (PE) (Sturbois-Balcerzak et al.,2001 [PubMed 11084049]).
Rose, J. Phd, et al. Mol. Med. (2010) In press :Tomohiro, S., et al. Biochem. J. 418(2):421-429(2009)Olsen, J.V., et al. Cell 127(3):635-648(2006)Sturbois-Balcerzak, B., et al. J. Biol. Chem. 276(11):8205-8212(2001)Stone, S.J., et al. J. Biol. Chem. 275(44):34534-34540(2000)
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