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ZFYVE27 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q5T4F4
Clone Names 110726280
Peptide ID 110726280
Additional Information
Gene ID 118813
Other Names Protrudin, Zinc finger FYVE domain-containing protein 27, ZFYVE27
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZFYVE27
Synonyms SPG33 {ECO:0000303|PubMed:24668814}
Function Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (PubMed:17082457). Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA- dependent manner (PubMed:19289470). Contributes to both the formation and stabilization of the tubular ER network (PubMed:24668814). Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections (PubMed:23969831). Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner (PubMed:21976701).
Cellular Location Recycling endosome membrane {ECO:0000250|UniProtKB:Q6P7B7}; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, growth cone membrane {ECO:0000250|UniProtKB:Q3TXX3}; Multi-pass membrane protein. Note=Localizes at both dendrites and axons (By similarity). Localizes to endoplasmic reticulum tubular network. {ECO:0000250|UniProtKB:Q3TXX3, ECO:0000269|PubMed:23969831, ECO:0000269|PubMed:24668814}
Research Areas
Citations (0)

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This gene encodes a protein with several transmembranedomains, a Rab11-binding domain and a lipid-binding FYVE fingerdomain. The encoded protein appears to promote neurite formation. Amutation in this gene has been reported to be associated withhereditary spastic paraplegia, however the pathogenicity of themutation, which may simply represent a polymorphism, is unclear.


Saita, S., et al. J. Biol. Chem. 284(20):13766-13777(2009)Martignoni, M., et al. Am. J. Hum. Genet. 83(1):127-128(2008)Shirane, M., et al. Science 314(5800):818-821(2006)Mannan, A.U., et al. Am. J. Hum. Genet. 79(2):351-357(2006)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)

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$ 80.00
Cat# BP17130a
Availability: In Stock
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