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ZFYVE27 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q5T4F4 |
|---|---|
| Clone Names | 110726280 |
| Gene ID | 118813 |
|---|---|
| Other Names | Protrudin, Zinc finger FYVE domain-containing protein 27, ZFYVE27 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ZFYVE27 |
|---|---|
| Synonyms | SPG33 {ECO:0000303|PubMed:24668814} |
| Function | Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (PubMed:17082457). Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner (PubMed:19289470). Contributes to both the formation and stabilization of the tubular ER network (PubMed:24668814). Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections (PubMed:23969831). Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner (PubMed:21976701). |
| Cellular Location | Recycling endosome membrane {ECO:0000250|UniProtKB:Q6P7B7}; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, growth cone membrane {ECO:0000250|UniProtKB:Q3TXX3}; Multi-pass membrane protein. Note=Localizes at both dendrites and axons (By similarity). Localizes to endoplasmic reticulum tubular network {ECO:0000250|UniProtKB:Q3TXX3, ECO:0000269|PubMed:23969831, ECO:0000269|PubMed:24668814} |
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Background
This gene encodes a protein with several transmembranedomains, a Rab11-binding domain and a lipid-binding FYVE fingerdomain. The encoded protein appears to promote neurite formation. Amutation in this gene has been reported to be associated withhereditary spastic paraplegia, however the pathogenicity of themutation, which may simply represent a polymorphism, is unclear.
References
Saita, S., et al. J. Biol. Chem. 284(20):13766-13777(2009)Martignoni, M., et al. Am. J. Hum. Genet. 83(1):127-128(2008)Shirane, M., et al. Science 314(5800):818-821(2006)Mannan, A.U., et al. Am. J. Hum. Genet. 79(2):351-357(2006)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
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