|Other Names||Protrudin, Zinc finger FYVE domain-containing protein 27, ZFYVE27|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation.|
|Cellular Location||Recycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, growth cone membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein Note=Localizes at both dendrites and axons.|
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This gene encodes a protein with several transmembranedomains, a Rab11-binding domain and a lipid-binding FYVE fingerdomain. The encoded protein appears to promote neurite formation. Amutation in this gene has been reported to be associated withhereditary spastic paraplegia, however the pathogenicity of themutation, which may simply represent a polymorphism, is unclear.
Saita, S., et al. J. Biol. Chem. 284(20):13766-13777(2009)Martignoni, M., et al. Am. J. Hum. Genet. 83(1):127-128(2008)Shirane, M., et al. Science 314(5800):818-821(2006)Mannan, A.U., et al. Am. J. Hum. Genet. 79(2):351-357(2006)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
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