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CDC42EP2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O14613
Clone Names 110717025
Peptide ID 110717025
Additional Information
Gene ID 10435
Other Names Cdc42 effector protein 2, Binder of Rho GTPases 1, CDC42EP2, BORG1, CEP2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDC42EP2
Synonyms BORG1, CEP2
Function Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.
Cellular Location Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton
Tissue Location Highly expressed in the heart. Weakly expressed in the pancreas and liver
Research Areas
Citations (0)

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CDC42, a small Rho GTPase, regulates the formation ofF-actin-containing structures through its interaction with thedownstream effector proteins. The protein encoded by this gene is amember of the Borg family of CDC42 effector proteins. Borg familyproteins contain a CRIB (Cdc42/Rac interactive-binding) domain.They bind to, and negatively regulate the function of, CDC42.Coexpression of this protein with dominant negative mutant CDC42protein in fibroblast was found to induce pseudopodia formation,which suggested a role of this protein in actin filament assemblyand cell shape control.


Xue, Y., et al. Int. J. Cancer 118(12):2965-2972(2006)Joberty, G., et al. Nat. Cell Biol. 3(10):861-866(2001)Hirsch, D.S., et al. J. Biol. Chem. 276(2):875-883(2001)Joberty, G., et al. Mol. Cell. Biol. 19(10):6585-6597(1999)Burbelo, P.D., et al. Proc. Natl. Acad. Sci. U.S.A. 96(16):9083-9088(1999)

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$ 80.00
Cat# BP17133b
Availability: In Stock
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