|Other Names||Contactin-associated protein-like 4, Cell recognition molecule Caspr4, CNTNAP4, CASPR4, KIAA1763|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system (By similarity).|
|Cellular Location||Cell junction, synapse, presynaptic cell membrane; Single-pass type I membrane protein. Note=Specifically present within the presynaptic compartment of synapses.|
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This gene product belongs to the neurexin family, membersof which function in the vertebrate nervous system as cell adhesionmolecules and receptors. This protein, like other neurexinproteins, contains epidermal growth factor repeats and laminin Gdomains. In addition, it includes an F5/8 type C domain,discoidin/neuropilin- and fibrinogen-like domains, andthrombospondin N-terminal-like domains. Alternative splicingresults in two transcript variants encoding different isoforms.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008) :Nordgard, S.H., et al. Genes Chromosomes Cancer 47(8):680-696(2008)Kim, J.M., et al. DNA Res. 13(6):275-286(2006)
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