Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
ACACA Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13085 |
|---|---|
| Clone Names | 110729002 |
| Gene ID | 31 |
|---|---|
| Other Names | Acetyl-CoA carboxylase 1, ACC1, ACC-alpha, Biotin carboxylase, ACACA, ACAC, ACC1, ACCA |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ACACA (HGNC:84) |
|---|---|
| Synonyms | ACAC, ACC1, ACCA |
| Function | Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656, PubMed:20457939, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656, PubMed:20457939, PubMed:29899443). |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5SWU9} |
| Tissue Location | Expressed in brain, placenta, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Acetyl-CoA carboxylase (ACC) is a complex multifunctionalenzyme system. ACC is a biotin-containing enzyme which catalyzesthe carboxylation of acetyl-CoA to malonyl-CoA, the rate-limitingstep in fatty acid synthesis. There are two ACC forms, alpha andbeta, encoded by two different genes. ACC-alpha is highly enrichedin lipogenic tissues. The enzyme is under long term control at thetranscriptional and translational levels and under short termregulation by the phosphorylation/dephosphorylation of targetedserine residues and by allosteric transformation by citrate orpalmitoyl-CoA. Multiple alternatively spliced transcript variantsdivergent in the 5' sequence and encoding distinct isoforms havebeen found for this gene.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Kim, C.W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(21):9626-9631(2010)Zhao, L.F., et al. Endocr. J. 57(4):317-324(2010)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
