|Other Names||Acetyl-CoA carboxylase 1, ACC1, ACC-alpha, Biotin carboxylase, ACACA, ACAC, ACC1, ACCA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ACAC, ACC1, ACCA|
|Function||Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.|
|Tissue Location||Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver|
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Provided below are standard protocols that you may find useful for product applications.
Acetyl-CoA carboxylase (ACC) is a complex multifunctionalenzyme system. ACC is a biotin-containing enzyme which catalyzesthe carboxylation of acetyl-CoA to malonyl-CoA, the rate-limitingstep in fatty acid synthesis. There are two ACC forms, alpha andbeta, encoded by two different genes. ACC-alpha is highly enrichedin lipogenic tissues. The enzyme is under long term control at thetranscriptional and translational levels and under short termregulation by the phosphorylation/dephosphorylation of targetedserine residues and by allosteric transformation by citrate orpalmitoyl-CoA. Multiple alternatively spliced transcript variantsdivergent in the 5' sequence and encoding distinct isoforms havebeen found for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Kim, C.W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(21):9626-9631(2010)Zhao, L.F., et al. Endocr. J. 57(4):317-324(2010)
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