|Other Names||Chromobox protein homolog 2, CBX2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780).|
|Cellular Location||Nucleus. Chromosome. Note=Localized in distinct foci on chromatin and in chromocenters. Localizes to the inactive X chromosome. Seems to be recruited to H3K27me3, H3K9ac and H3K3me2 sites on chromatin.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a component of the polycomb multiproteincomplex, which is required to maintain the transcriptionallyrepressive state of many genes throughout development via chromatinremodeling and modification of histones. Disruption of this gene inmice results in male-to-female gonadal sex reversal. Mutations inthis gene are also associated with gonadal dysgenesis in humans.Alternatively spliced transcript variants encoding differentisoforms have been noted for this gene.
Biason-Lauber, A., et al. Am. J. Hum. Genet. 84(5):658-663(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Agrawal, N., et al. PLoS ONE 3 (12), E4032 (2008) :Garcia, E., et al. EMBO J. 18(12):3404-3418(1999)Katoh-Fukui, Y., et al. Nature 393(6686):688-692(1998)
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