|Other Names||Bone morphogenetic protein 3, BMP-3, Bone morphogenetic protein 3A, BMP-3A, Osteogenin, BMP3, BMP3A|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1714a was selected from the N-term region of human Bmp3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.|
|Tissue Location||Expressed in adult and fetal cartilage.|
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Provided below are standard protocols that you may find useful for product applications.
The BMPs belong to the TGF-Beta superfamilyBMPs stimulate the production of bone matrix proteins and thereby alter stromal cell and osteoclast proliferation, a key step in bone marrow development. In addition to promoting ectopic bone and cartilage development, BMPs regulate the growth, differentiation, chemotaxis, proliferation, and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells, and neuronal cells. BMPs also play a role in dorsal/ventral patterning. BMP3, highly expressed in lung, ovary and small intestine, participates in cartilage and bone formation. BMP3 and BMP2 genes map to conserved regions between human and mouse.
Jin, Y., et al., Histol. Histopathol. 16(4):1013-1019 (2001).Tabas, J.A., et al., Genomics 9(2):283-289 (1991).Dickinson, M.E., et al., Genomics 6(3):505-520 (1990).Wozney, J.M., et al., Science 242(4885):1528-1534 (1988).
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