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GCNT1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
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- BACKGROUND
| Primary Accession | Q02742 |
|---|---|
| Clone Names | 100617100 |
| Gene ID | 2650 |
|---|---|
| Other Names | Beta-1, 3-galactosyl-O-glycosyl-glycoprotein beta-1, 6-N-acetylglucosaminyltransferase, Core 2-branching enzyme, Core2-GlcNAc-transferase, C2GNT, Core 2 GNT, GCNT1, NACGT2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GCNT1 |
|---|---|
| Synonyms | NACGT2 |
| Function | Glycosyltransferase that catalyzes the transfer of an N- acetylglucosamine (GlcNAc) moiety in beta1-6 linkage from UDP-GlcNAc onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan (PubMed:1329093, PubMed:23027862). The catalysis is metal ion- independent and occurs with inversion of the anomeric configuration of sugar donor (By similarity). Selectively involved in synthesis of mucin-type core 2 O-glycans that serve as scaffolds for the display of selectin ligand sialyl Lewis X epitope by myeloid cells, with an impact on homeostasis and recruitment to inflammatory sites (By similarity). Can also act on glycolipid substrates. Transfers GlcNAc moiety to GalGb4Cer globosides in a reaction step to the synthesis of stage- specific embryonic antigen 1 (SSEA-1) determinant (By similarity). Can use Galbeta1-3GalNAcalpha1- and Galbeta1-3GalNAcbeta1- oligosaccharide derivatives as acceptor substrates (By similarity). |
| Cellular Location | Golgi apparatus membrane; Single-pass type II membrane protein. Note=Also detected in the trans-Golgi network |
| Tissue Location | Highly expressed in activated T-lymphocytes and myeloid cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of thebeta-1,6-N-acetylglucosaminyltransferase gene family. It isessential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAcstructures and the core 2 O-glycan branch. The gene coding thisenzyme was originally mapped to 9q21, but was later localized to9q13. Multiple alternatively spliced variants, encoding the sameprotein, have been identified.
References
Hatakeyama, S., et al. Int. J. Cancer 127(5):1052-1059(2010)Brockhausen, I., et al. Biochim. Biophys. Acta 1790(10):1244-1257(2009)St Hill, C.A., et al. BMC Cancer 9, 79 (2009) :Nagaraj, S., et al. Pancreas 37(3):321-327(2008)Julien, S., et al. J. Immunol. 179(9):5701-5710(2007)
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