|Other Names||Interleukin-19, IL-19, Melanoma differentiation-associated protein-like protein, NG1, IL19, ZMDA1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).|
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The protein encoded by this gene is a cytokine thatbelongs to the IL10 cytokine subfamily. This cytokine is found tobe preferentially expressed in monocytes. It can bind the IL20receptor complex and lead to the activation of the signaltransducer and activator of transcription 3 (STAT3). A similarcytokine in mouse is reported to up-regulate the expression of IL6and TNF-alpha and induce apoptosis, which suggests a role of thiscytokine in inflammatory responses. Alternatively splicedtranscript variants encoding the distinct isoforms have beendescribed.
Beckers, M.M., et al. Eur. J. Intern. Med. 21(4):289-292(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Ryckman, K.K., et al. PLoS ONE 5 (8), E12273 (2010) :
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