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IL19 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UHD0 |
|---|---|
| Clone Names | 100623056 |
| Gene ID | 29949 |
|---|---|
| Other Names | Interleukin-19, IL-19, Melanoma differentiation-associated protein-like protein, NG1, IL19, ZMDA1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | IL19 |
|---|---|
| Synonyms | ZMDA1 |
| Function | Cytokine that functions as an anti-inflammatory and proangiogenic factor (PubMed:34932373). Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13 (PubMed:16365913). Produced by osteocytes, stimulates granulopoiesis and neutrophil formation (By similarity). Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB (PubMed:12351624). In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3 (PubMed:11564763). |
| Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a cytokine thatbelongs to the IL10 cytokine subfamily. This cytokine is found tobe preferentially expressed in monocytes. It can bind the IL20receptor complex and lead to the activation of the signaltransducer and activator of transcription 3 (STAT3). A similarcytokine in mouse is reported to up-regulate the expression of IL6and TNF-alpha and induce apoptosis, which suggests a role of thiscytokine in inflammatory responses. Alternatively splicedtranscript variants encoding the distinct isoforms have beendescribed.
References
Beckers, M.M., et al. Eur. J. Intern. Med. 21(4):289-292(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Ryckman, K.K., et al. PLoS ONE 5 (8), E12273 (2010) :
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