|Other Names||B-cell CLL/lymphoma 7 protein family member B, Hom s 3, BCL7B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity).|
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This gene encodes a member of the BCL7 family includingBCL7A, BCL7B and BCL7C proteins. This member is BCL7B, whichcontains a region that is highly similar to the N-terminal segmentof BCL7A or BCL7C proteins. The BCL7A protein is encoded by thegene known to be directly involved in a three-way genetranslocation in a Burkitt lymphoma cell line. This gene is locatedat a chromosomal region commonly deleted in Williams syndrome. Thisgene is highly conserved from C. elegans to human. Multiplealternatively spliced transcript variants have been found for thisgene.
Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162(2010)Kathiresan, S., et al. Nat. Genet. 40(2):189-197(2008)Willer, C.J., et al. Nat. Genet. 40(2):161-169(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)Jadayel, D.M., et al. Gene 224 (1-2), 35-44 (1998) :
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