|Other Names||Leptin receptor, LEP-R, HuB219, OB receptor, OB-R, CD295, LEPR, DB, OBR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary Low level in lung and kidney. Isoform B is highly expressed in hypothalamus|
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The protein encoded by this gene belongs to the gp130family of cytokine receptors that are known to stimulate genetranscription via activation of cytosolic STAT proteins. Thisprotein is a receptor for leptin (an adipocyte-specific hormonethat regulates body weight), and is involved in the regulation offat metabolism, as well as in a novel hematopoietic pathway that isrequired for normal lymphopoiesis. Mutations in this gene have beenassociated with obesity and pituitary dysfunction. Alternativelyspliced transcript variants encoding different isoforms have beendescribed for this gene. It is noteworthy that this gene and LEPROTgene (GeneID:54741) share the same promoter and the first 2 exons,however, encode distinct proteins (PMID:9207021).
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)de Luis, D.A., et al. Ann. Nutr. Metab. 57(2):89-94(2010)Louis, G.W., et al. J. Neurosci. 30(34):11278-11287(2010)Sarzynski, M.A., et al. Int J Obes (Lond) (2010) In press :
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