|Other Names||Bone morphogenetic protein 5, BMP-5, BMP5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1716a was selected from the N-term region of human Bmp5 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Induces cartilage and bone formation.|
|Tissue Location||Expressed in the lung and liver.|
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Provided below are standard protocols that you may find useful for product applications.
Bmp5 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.
Luo, J., et al., Prostate 51(3):189-200 (2002).Jin, Y., et al., Histol. Histopathol. 16(4):1013-1019 (2001).Sakaue, M., et al., Biochem. Biophys. Res. Commun. 221(3):768-772 (1996).Hahn, G.V., et al., Genomics 14(3):759-762 (1992).Celeste, A.J., et al., Proc. Natl. Acad. Sci. U.S.A. 87(24):9843-9847 (1990).
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