|Other Names||NACHT, LRR and PYD domains-containing protein 7, Nucleotide-binding oligomerization domain protein 12, PYRIN-containing APAF1-like protein 3, NLRP7, NALP7, NOD12, PYPAF3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||NALP7, NOD12, PYPAF3|
|Function||Inhibits CASP1/caspase-1-dependent IL1B secretion.|
|Tissue Location||Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. Not detected in skeletal muscle.|
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This gene encodes a member of the NACHT, leucine richrepeat, and PYD containing (NLRP) protein family. It has anN-terminal pyrin domain, followed by a NACHT domain, aNACHT-associated domain (NAD), and a C-terminal leucine-rich repeat(LRR) region. NLRP proteins are implicated in the activation ofproinflammatory caspases through multiprotein complexes calledinflammasomes. This gene may act as a feedback regulator ofcaspase-1-dependent interleukin 1-beta secretion. Alternativesplicing results in multiple transcript variants encoding differentisoforms.
Cummings, J.R., et al. Tissue Antigens 76(1):48-56(2010)de Sa Pinheiro, A., et al. Biomol NMR Assign 3(2):207-209(2009)Slim, R., et al. Clin. Genet. 76(3):292-295(2009)Wang, C.M., et al. J. Med. Genet. 46(8):569-575(2009)Deveault, C., et al. Hum. Mol. Genet. 18(5):888-897(2009)
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