|Other Names||Ly-6/neurotoxin-like protein 1, Secreted Ly-6/uPAR domain-containing protein 2, Secreted Ly-6/uPAR-related protein 2, SLURP-2, LYNX1, SLURP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). In brain, isoform 2 modulates functional properties of nAChRs to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha(4)beta(2) nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha(4)beta(2) nAChRs (By similarity). Prevents plasticity in the primary visual cortex late in life (By similarity). In keratinocytes, isoform 3 delays differentiation and prevents apoptosis.|
|Cellular Location||Isoform 1: Secreted. Isoform 3: Secreted.|
|Tissue Location||Isoform 3 is expressed at highest levels in cervix and esophagus, followed by adult and fetal skin. Expressed at lower levels in brain, lung, stomach, small intestine, colon, rectum, uterus, and thymus. Not detected in spleen nor bone marrow. In the epidermis, predominantly produced by keratinocytes of the suprabasal epidermal compartment (at protein level). In attached gingiva, produced at highest levels by basal cells located in the lowermost epithelial layers (at protein level). Up- regulated 3-fold in psoriatic lesional skin. Detected in serum (at protein level).|
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This gene encodes a member of the Ly-6/neurotoxin genefamily, a group of lymphocyte antigens that attach to the cellsurface by a glycosylphosphatidylinositol anchor and have a uniquestructure showing conserved 8-10 cysteine residues with acharacteristic spacing pattern. Functional analysis indicates thatthis protein is not a ligand or neurotransmitter but has thecapacity to enhance nicotinic acetylcholine receptor function inthe presence of acetylcholine. This gene may also play a role inthe pathogenesis of psoriasis vulgaris. Alternatively splicedvariants encoding different isoforms have been identified.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Choi, S.H., et al. Int. J. Oncol. 35(3):601-607(2009)Song, P., et al. Cancer Res. 68(12):4693-4700(2008)Arredondo, J., et al. Biochem. Pharmacol. 74(8):1315-1319(2007)Lee, J.W., et al. Oncol. Rep. 16(6):1211-1214(2006)
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