|Other Names||E3 ubiquitin-protein ligase TRIM68, 632-, RING finger protein 137, SSA protein SS-56, SS-56, Tripartite motif-containing protein 68, TRIM68, GC109, RNF137, SS56|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GC109, RNF137, SS56|
|Function||Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.|
|Cellular Location||Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with AR in nucleus|
|Tissue Location||Widely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could be restricted to androgen-dependent cells.|
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The protein encoded by this gene contains a RING fingerdomain, a motif present in a variety of functionally distinctproteins and known to be involved in protein-protein andprotein-DNA interactions. This gene is expressed in many cancercell lines. Its expression in normal tissues, however, was found tobe restricted to prostate. This gene was also found to bedifferentially expressed in androgen-dependent versusandrogen-independent prostate cancer cells.
Malhotra, A., et al. Diabetes Metab. Res. Rev. 25(8):740-747(2009)Miyajima, N., et al. Cancer Res. 68(9):3486-3494(2008)Chang, G.T., et al. Eur. J. Cancer 37(16):2129-2134(2001)Billaut-Mulot, O., et al. J. Clin. Invest. 108(6):861-869(2001)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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