|Other Names||Bone morphogenetic protein 6, BMP-6, VG-1-related protein, VG-1-R, VGR-1, BMP6, VGR|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1717a was selected from the N-term region of human Bmp6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Induces cartilage and bone formation.|
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Provided below are standard protocols that you may find useful for product applications.
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, Bmp6 has a proposed role in early development. In addition, the fact that BMP6 is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
Lories, R.J., et al., Arthritis Rheum. 48(10):2807-2818 (2003).Bobacz, K., et al., Arthritis Rheum. 48(9):2501-2508 (2003).Tamada, H., et al., Biochim. Biophys. Acta 1395(3):247-251 (1998).Rickard, D.J., et al., J. Clin. Invest. 101(2):413-422 (1998).Olavesen, M.G., et al., Genomics 46(2):303-306 (1997).
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