|Other Names||cAMP-specific 3', 5'-cyclic phosphodiesterase 4A, DPDE2, PDE46, PDE4A, DPDE2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.|
|Cellular Location||Isoform 1: Cytoplasm, perinuclear region. Isoform 4: Membrane; Peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes Isoform 7: Cytoplasm. Membrane. Note=Predominantly cytoplasmic|
|Tissue Location||Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Cyclic nucleotides are important second messengers thatregulate and mediate a number of cellular responses toextracellular signals, such as hormones, light, andneurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs)regulate the cellular concentrations of cyclic nucleotides andthereby play a role in signal transduction. PDE4A is a class IVcAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed8009369]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Selige, J., et al. J. Cell. Physiol. 223(2):317-326(2010)Bjorgo, E., et al. Mol. Cell. Biol. 30(7):1660-1672(2010)Singh, D., et al. Respir. Res. 11, 26 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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