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PDE4A Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P27815 |
|---|---|
| Clone Names | 100427220 |
| Gene ID | 5141 |
|---|---|
| Other Names | cAMP-specific 3', 5'-cyclic phosphodiesterase 4A, DPDE2, PDE46, PDE4A, DPDE2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PDE4A |
|---|---|
| Synonyms | DPDE2 |
| Function | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. |
| Cellular Location | [Isoform 1]: Cytoplasm, perinuclear region [Isoform 3]: Cytoplasm, cytosol [Isoform 6]: Cytoplasm, perinuclear region |
| Tissue Location | [Isoform 1]: Expressed in lymphoid cell subsets including CD8-positive T cells and T-helper 2 cells. Expressed in dendritic cells. [Isoform 6]: Expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Cyclic nucleotides are important second messengers thatregulate and mediate a number of cellular responses toextracellular signals, such as hormones, light, andneurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs)regulate the cellular concentrations of cyclic nucleotides andthereby play a role in signal transduction. PDE4A is a class IVcAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed8009369]).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Selige, J., et al. J. Cell. Physiol. 223(2):317-326(2010)Bjorgo, E., et al. Mol. Cell. Biol. 30(7):1660-1672(2010)Singh, D., et al. Respir. Res. 11, 26 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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