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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   PDE4A Antibody (N-term) Blocking Peptide   

PDE4A Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P27815
Clone Names 100427220
Peptide ID 100427220
Additional Information
Gene ID 5141
Other Names cAMP-specific 3', 5'-cyclic phosphodiesterase 4A, DPDE2, PDE46, PDE4A, DPDE2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDE4A
Synonyms DPDE2
Function Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Cellular Location Isoform 1: Cytoplasm, perinuclear region. Isoform 4: Membrane; Peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes Isoform 7: Cytoplasm. Membrane. Note=Predominantly cytoplasmic
Tissue Location Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level)
Research Areas
Citations (0)

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Cyclic nucleotides are important second messengers thatregulate and mediate a number of cellular responses toextracellular signals, such as hormones, light, andneurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs)regulate the cellular concentrations of cyclic nucleotides andthereby play a role in signal transduction. PDE4A is a class IVcAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed8009369]).


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Selige, J., et al. J. Cell. Physiol. 223(2):317-326(2010)Bjorgo, E., et al. Mol. Cell. Biol. 30(7):1660-1672(2010)Singh, D., et al. Respir. Res. 11, 26 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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$ 80.00
Cat# BP17181a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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