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H1FOO Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8IZA3
Clone Names 100427236
Additional Information
Gene ID 132243
Other Names Histone H1oo, Oocyte-specific histone H1, Oocyte-specific linker histone H1, osH1, H1FOO, H1OO, OSH1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name H1-8 (HGNC:18463)
Function May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity).
Cellular Location Cytoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837}. Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837}
Tissue Location Oocyte-specific..
Research Areas
Citations (0)
citation

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Background

Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. Nucleosomes consist of approximately 146 bp of DNAwrapped around a histone octamer composed of pairs of each of thefour core histones (H2A, H2B, H3, and H4). The chromatin fiber isfurther compacted through the interaction of a linker histone, H1,with the DNA between the nucleosomes to form higher order chromatinstructures. The protein encoded is a member of the histone H1family. This gene contains introns, unlike most histone genes. Theprotein encoded is a member of the histone H1 family. The relatedmouse gene is expressed only in oocytes.

References

Mizusawa, Y., et al. Fertil. Steril. 93(4):1134-1141(2010)Tanaka, M., et al. Biol. Reprod. 72(1):135-142(2005)Teranishi, T., et al. Dev. Biol. 266(1):76-86(2004)Gao, S., et al. Dev. Biol. 266(1):62-75(2004)Tanaka, Y., et al. Biochem. Biophys. Res. Commun. 304(2):351-357(2003)

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$ 277.78
Cat# BP17183c
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