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NKX3-1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q99801 |
|---|---|
| Clone Names | 100427213 |
| Gene ID | 4824 |
|---|---|
| Other Names | Homeobox protein Nkx-31, Homeobox protein NK-3 homolog A, NKX3-1, NKX31, NKX3A |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NKX3-1 (HGNC:7838) |
|---|---|
| Function | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11137288} |
| Tissue Location | Highly expressed in the prostate and, at a lower level, in the testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The homeodomain-containing transcription factor NKX3-1 isa putative prostate tumor suppressor that is expressed in a largelyprostate-specific and androgen-regulated manner. Loss of NKX3-1protein expression is a common finding in human prostate carcinomasand prostatic intraepithelial neoplasia.
References
Kim, S.T., et al. Prostate 70(16):1729-1738(2010)Takata, R., et al. Nat. Genet. 42(9):751-754(2010)Gurel, B., et al. Am. J. Surg. Pathol. 34(8):1097-1105(2010)Bowen, C., et al. Cancer Res. 70(8):3089-3097(2010)Kunderfranco, P., et al. PLoS ONE 5 (5), E10547 (2010) :
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