ORAI3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BRQ5 |
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Clone Names | 100603200 |
Gene ID | 93129 |
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Other Names | Protein orai-3, Transmembrane protein 142C, ORAI3, TMEM142C |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ORAI3 |
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Synonyms | TMEM142C |
Function | Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1. |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Expressed in both naive and effector T helper cells with higher levels in effector cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import (By similarity).
References
Motiani, R.K., et al. J. Biol. Chem. 285(25):19173-19183(2010)Bogeski, I., et al. Sci Signal 3 (115), RA24 (2010) :Schindl, R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(46):19623-19628(2009)Lee, K.P., et al. Proc. Natl. Acad. Sci. U.S.A. 106(34):14687-14692(2009)Frischauf, I., et al. J. Biol. Chem. 284(32):21696-21706(2009)
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