|Other Names||Potassium voltage-gated channel subfamily A member 6, Voltage-gated potassium channel HBK2, Voltage-gated potassium channel subunit Kv16, KCNA6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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Potassium channels represent the most complex class ofvoltage-gated ion channels from both functional and structuralstandpoints. Their diverse functions include regulatingneurotransmitter release, heart rate, insulin secretion, neuronalexcitability, epithelial electrolyte transport, smooth musclecontraction, and cell volume. Four sequence-related potassiumchannel genes - shaker, shaw, shab, and shal - have been identifiedin Drosophila, and each has been shown to have human homolog(s).This gene encodes a member of the potassium channel, voltage-gated,shaker-related subfamily. This member contains sixmembrane-spanning domains with a shaker-type repeat in the fourthsegment. It belongs to the delayed rectifier class. The codingregion of this gene is intronless, and the gene is clustered withgenes KCNA1 and KCNA5 on chromosome 12.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Tan, K.M., et al. Neurology 70(20):1883-1890(2008)Yusifov, T., et al. Proc. Natl. Acad. Sci. U.S.A. 105(1):376-381(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)
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