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Bmp7 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P18075
Other Accession NP_001710
Clone Names 2080409
Additional Information
Gene ID 655
Other Names Bone morphogenetic protein 7, BMP-7, Osteogenic protein 1, OP-1, Eptotermin alfa, BMP7, OP1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1718a was selected from the N-term region of human Bmp7 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BMP7
Synonyms OP1
Function Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:31208997). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A (PubMed:9748228, PubMed:12667445). Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:12478285). For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor (PubMed:31208997). Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509).
Cellular Location Secreted.
Tissue Location Expressed in the kidney and bladder. Lower levels seen in the brain
Research Areas
Citations (0)
citation

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Background

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, BMP7 has a proposed role in early development. In addition, the fact that BMP7 is closely related to BMP5 and BMP6 has lead to speculation of possible bone inductive activity.

References

Merrihew, C., et al., J. Orthop. Res. 21(5):899-907 (2003).Greenwald, J., et al., Mol. Cell 11(3):605-617 (2003).Maric, I., et al., J. Cell. Physiol. 196(2):258-264 (2003).Im, H.J., et al., J. Biol. Chem. 278(28):25386-25394 (2003).Lee, M.J., et al., J. Immunol. 170(5):2557-2563 (2003).

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$ 277.78
Cat# BP1718a
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