NOX1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y5S8 |
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Clone Names | 100617236 |
Gene ID | 27035 |
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Other Names | NADPH oxidase 1, NOX-1, 1---, Mitogenic oxidase 1, MOX-1, NADH/NADPH mitogenic oxidase subunit P65-MOX, NOH-1, NOX1, MOX1, NOH1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NOX1 |
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Synonyms | MOX1, NOH1 |
Function | NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. |
Cellular Location | Cell projection, invadopodium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
Tissue Location | [Isoform NOH-1L]: Detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
Voltage-gated proton (hydrogen) channels play an importantrole in cellular defense against acidic stress. They are uniqueamong ion channels with respect to their extremely highselectivity, marked temperature dependence, and unitaryconductance, which is 3 orders of magnitude lower than that of mostother ion channels. NOX1 is a homolog of the catalytic subunit ofthe superoxide-generating NADPH oxidase of phagocytes, gp91phox.Two transcript variants encoding different isoforms have been foundfor this gene.
References
Sancho, P., et al. J. Biol. Chem. 285(32):24815-24824(2010)van Bruggen, R., et al. Blood 115(26):5398-5400(2010)Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)Malec, V., et al. Free Radic. Biol. Med. 48(12):1626-1635(2010)Manea, A., et al. Biochem. Biophys. Res. Commun. 396(4):901-907(2010)
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