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ITM2C Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NQX7
Clone Names 100712033
Peptide ID 100712033
Additional Information
Gene ID 81618
Other Names Integral membrane protein 2C, Cerebral protein 14, Transmembrane protein BRI3, CT-BRI3, ITM2C, BRI3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITM2C
Synonyms BRI3
Function Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
Cellular Location Lysosome membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein
Tissue Location High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs.
Research Areas
Citations (0)

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Background

Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).

References

Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Matsuda, S., et al. J. Biol. Chem. 284(23):15815-15825(2009)Matsuda, S., et al. Mol Neurodegener 4, 41 (2009) :Gong, Y., et al. BMB Rep 41(4):287-293(2008)

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$ 80.00
Cat# BP17192a
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