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ASF1A Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y294 |
|---|---|
| Clone Names | 100430146 |
| Gene ID | 25842 |
|---|---|
| Other Names | Histone chaperone ASF1A, Anti-silencing function protein 1 homolog A, hAsf1, hAsf1a, CCG1-interacting factor A, CIA, hCIA, ASF1A |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ASF1A {ECO:0000303|PubMed:10759893, ECO:0000312|HGNC:HGNC:20995} |
|---|---|
| Function | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10759893, PubMed:11897662, PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198). Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51 (PubMed:29478807). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:21454524, PubMed:29408485). Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit (PubMed:15621527). |
| Cellular Location | Nucleus. Chromosome |
| Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the H3/H4 family of histonechaperone proteins and is similar to the anti-silencing function-1gene in yeast. The protein is a key component of a histone donorcomplex that functions in nucleosome assembly. It interacts withhistones H3 and H4, and functions together with a chromatinassembly factor during DNA replication and repair. [provided byRefSeq].
References
Jasencakova, Z., et al. Mol. Cell 37(5):736-743(2010)Newton-Cheh, C., et al. Nat. Genet. 41(4):399-406(2009)Banumathy, G., et al. Mol. Cell. Biol. 29(3):758-770(2009)Ambagala, A.P., et al. J. Virol. 83(1):200-209(2009)Pilyugin, M., et al. PLoS ONE 4 (12), E8328 (2009) :
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