|Other Names||cAMP-dependent protein kinase type I-beta regulatory subunit, PRKAR1B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.|
|Cellular Location||Cell membrane.|
|Tissue Location||Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible|
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Provided below are standard protocols that you may find useful for product applications.
Cyclic AMP-dependent protein kinase A (PKA) is anessential enzyme in the signaling pathway of the second messengercAMP. Through phosphorylation of target proteins, PKA controls manybiochemical events in the cell including regulation of metabolism,ion transport, and gene transcription. The PKA holoenzyme iscomposed of 2 regulatory and 2 catalytic subunits and dissociatesfrom the regulatory subunits upon binding of cAMP.[supplied byOMIM].
Silva, L.K., et al. Eur. J. Hum. Genet. (2010) In press :Liu, Y.J., et al. Obesity (Silver Spring) (2010) In press :Zhan, X., et al. Anal. Biochem. 354(2):279-289(2006)Gullingsrud, J., et al. Structure 14(1):141-149(2006)Zhang, L., et al. Mol. Cell. Biol. 24(5):2169-2180(2004)
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